Upon entry into the target cell, the viral RNA genome is converted (reverse transcribed) into double-stranded DNA by a virally encoded reverse transcriptase that is transported along with the viral genome in the virus particle.The resulting viral DNA is then imported into the cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors.It is less infectious and progresses more slowly than HIV-1, resulting in fewer deaths.It is estimated to be more than 55% genetically distinct from HIV-1.1 While many commonly used antiretroviral drugs are active against HIV-2, non-nucleoside reverse transcriptase inhibitors (NNRTIs) like nevirapine and efavirenz do not work against it.A more practical concern are the tests used to diagnose HIV and monitor the level of virus in the body (viral load).Tests that are sensitive to the full range of subtypes (and to group O and HIV-2) do exist but may not be readily available in all settings.If you do not have an existing account within Passions Network, then you can join HIV Passions, and it will be 100% free.
It is very common in the high prevalence countries of Southern Africa, as well as in the horn of Africa and India.
Group O represents up to 5% of infections in several west and central African countries, and Group N and P have been rarely identified in Cameroon.
Within group M there are known to be at least nine genetically distinct subtypes of HIV-1. Additionally, different subtypes can combine genetic material to form a hybrid virus, known as a ‘circulating recombinant form’ (CRFs).
There are a number of options within HIV Passions to help connect members, including the following: HIV Positive ‘Groups’ allow members to find others who share very specific interests / similarities.
HIV Positive Forums allow members to post on topics of interest.